Ehlers-Danlos Syndrome is a rare syndrome that can cause a defect in the sound conducting mechanism of the middle ear, and which may result in hearing loss.
What is Ehlers-Danlos type 2?
A rare systemic disease characterized by generalized joint hypermobility with recurrent joint dislocations, redundant and hyperextensible skin with poor wound healing and abnormal scarring, easy bruising, and osteopenia/osteoporosis.
Does EDS affect facial features?
People who have vascular Ehlers-Danlos syndrome often share distinctive facial features of a thin nose, thin upper lip, small earlobes and prominent eyes. They also have thin, translucent skin that bruises very easily. In fair-skinned people, the underlying blood vessels are very visible through the skin.
Is Ehlers-Danlos type 3 Progressive?
EDS is a slowly progressive disease. EDS symptoms vary by type and range from mildly loose joints to life-threatening complications.
Can Ehlers Danlos cause tinnitus?
Tinnitus is common in several types of EDS. Many people also have dizziness (vertigo). Some very rare types of EDS affect the eyes.
Does EDS affect nails?
Abnormalities of the nails are frequently seen in clinical practice although there has been no specific study of these in people with EDS. Difficulty with hand function, coupled with painful upper and lower limb joints, may also make it difficult for someone to reach and cut their toenails.
What is Ehlers Danlos type 4?
Ehlers-Danlos syndrome type IV, the vascular type of Ehlers-Danlos syndromes (EDS), is an inherited connective tissue disorder defined by characteristic facial features (acrogeria) in most patients, translucent skin with highly visible subcutaneous vessels on the trunk and lower back, easy bruising, and severe arterial …
What mimics Ehlers-Danlos syndrome?
Tnxb−/− mice showed progressive skin hyperextensibility, similar to individuals with Ehlers–Danlos syndrome. Biomechanical testing confirmed increased deformability and reduced tensile strength of their skin.
Does EDS shorten your lifespan?
Patients with the classical and hypermobility forms of Ehlers-Danlos syndrome have a normal life expectancy. About 80% of patients with vascular Ehlers-Danlos syndrome will experience a major health event by age 40 and the life expectancy is shortened, with an average age of death of 48 years.
What are the features of Ehlers Danlos syndrome?
Features shared by many types include joint hypermobility and soft, velvety skin that is highly elastic (stretchy) and bruises easily. Mutations in a variety of genes may lead to EDS; however, the underlying genetic cause in some families is unknown.
What are vascular Ehlers-Danlos Syndrome (vEDS)?
Abstract As a type of Ehlers-Danlos syndrome (EDS), vascular EDs (vEDS) is typified by a number of characteristic facial features (eg, large eyes, small chin, sunken cheeks, thin nose and lips, lobeless ears).
What is the long-term outlook for people with Ehlers-Danlos syndrome (EDS)?
The long-term outlook ( prognosis) for people with Ehlers-Danlos syndromes (EDS) varies by subtype. The vascular type is typically the most severe form of EDS and is often associated with a shortened lifespan. People affected by vascular EDS have a median life expectancy of 48 years and many will have a major event by age 40.
What is mymyopathic Ehlers Danlos syndrome?
Myopathic EDS (mEDS) characterized by congenital muscle hypotonia, and/or muscle atrophy, that improves with age, Proximal joint contractures (joints of the knee, hip and elbow); and hypermobility of distal joints (joints of the ankles, wrists, feet and hands).
