Each 500mg of dose should be diluted with 100ml of compatible IV fluid, whilst for a 1gm dose use a 250ml bag. Infuse doses of 500mg over 20 minutes. Infuse doses of 500mg to 1gm over 40 to 60 minutes.
How do you give imipenem IV?
Recommend that the maximum total daily dosage not exceed 4 g/day. Administer 500 mg by intravenous infusion over 20 to 30 minutes. Administer 1000 mg by intravenous infusion over 40 to 60 minutes. In patients who develop nausea during the infusion, the rate of infusion may be slowed.
How do you give Tienam?
Method of administration TIENAM is to be reconstituted and further diluted (see section 6.2, 6.3 and 6.6) prior to administration. Each dose of ≤500 mg/500 mg should be given by intravenous infusion over 20 to 30 minutes. Each dose >500 mg/500 mg should be infused over 40 to 60 minutes.
Is imipenem soluble in water?
Product Info
| Cas No. | 74431-23-5 |
|---|---|
| Formula Wt. | 317.36 |
| Melting Point | 106-111°C |
| Solubility | Water 10 mg/ml, methanol 5 mg/ml, ethanol 0.2 mg/ml |
| Appearance | White to off white powder |
Can imipenem be given orally?
Absorption and distribution. Imipenem is not absorbed by the oral route. No accumulation of imipenem is reported following multiple dosing with cilastatin. Imipenem and cilastatin are both widely distributed in multiple fluids and tissues.
Can amikacin be given orally?
Amikacin may be administered once or twice a day and is usually given by the intravenous or intramuscular route, though it can be given via nebulization. There is no oral form available, as amikacin is not absorbed orally.
What is Tienam used for?
Tienam is an antibiotic used in complicated infections, generally in hospital. It has been used to treat infections of the lungs, the urinary tract (structures that carry urine), the abdomen, skin and the reproductive system. It can also be used in patients whose immune system is weakened when they have a fever.
Is imipenem safe in renal failure?
Based on the desired peak levels of imipenem, normal subjects should receive the fixed imipenem/cilastatin dose combination (500 mg/500 mg) q.i.d. and patients with acute renal failure should receive the same dose b.i.d. After starting treatment with either CAVH, CAVHD or continuous venovenous hemofiltration (CVVH), no …
How do you use imipenem injection?
When imipenem and cilastatin is injected intravenously, it is usually infused (injected slowly) over a period of 20 minutes to 1 hour every 6 or 8 hours. When imipenem and cilastatin is given intramuscularly, it is injected into the muscles of the buttocks or thigh once every 12 hours.
Which class of antibiotics is used for the treatment of serious Gram negative infections as well as infections with Mycobacterium tuberculosis?
Aminoglycosides are a class of antibiotics used mainly in the treatment of aerobic gram-negative bacilli infections, although they are also effective against other bacteria including Staphylococci and Mycobacterium tuberculosis. They are often used in combination with other antibiotics.
Can imipenem cause seizures?
Imipenem has been reported to cause CNS toxicity including seizures in 1.5-10% of patients.
How does tienam work in the body?
When Tienam is absorbed in the body, the imipenem component kills the bacteria that are causing the infection, while the cilastatin component blocks the dehypropeptidase enzyme in the kidney that normally breaks down imipenem. As a result, the antibiotic stays in the body and can work for longer.
What is the pH of tienam 500?
TIENAM I.V. is buffered with sodium bicarbonate to provide solutions in the pH range of 6.5 to 8.5. There is no significant change in pH when solutions are prepared and used as directed. TIENAM I.V. 250 contains 18.8 mg of sodium (0.8 mEq) and TIENAM I.V. 500 contains 37.5 mg of sodium (1.6 mEq).
What are the active substances in tienam?
Tienam contains two active substances: imipenem, which is an antibiotic belonging to the carbapenem family, and cilastatin, which is a ‘dehydropeptidase inhibitor’.
Is tienam available in the EU?
The medicine is available in all EU Member States under the trade name Tienam, as well under other trade names: Conet, Imipem, Primaxin, Tenacid and Zienam. The company that markets these medicines is Merck, Sharp & Dohme. Why was Tienam reviewed?
