Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments.
What is PLEC?
PLEC (Plectin) is a Protein Coding gene. Diseases associated with PLEC include Epidermolysis Bullosa Simplex, Ogna Type and Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 17. Among its related pathways are Apoptotic cleavage of cellular proteins and Cytoskeletal Signaling.
What is PLEC gene?
The PLEC gene provides instructions for making a protein called plectin. This protein is produced in many different tissues in the body, including skin and muscle. Within cells, plectin interacts with several molecules that make up the cell’s structural framework (the cytoskeleton).
Where is Plectin found?
At the cellular level, plectin is found at plasma membrane attachment sites of IFs and microfilaments, for instance, Z-disks in stratified muscle, dense plaques in smooth muscle, intercalated disks in cardiac muscle, HDs in the basal cell layer of stratified epithelia, desmosomes, and focal adhesions.
What is EB simplex?
Epidermolysis bullosa simplex is one of a group of genetic conditions called epidermolysis bullosa that cause the skin to be very fragile and to blister easily. Blisters and areas of skin loss (erosions) occur in response to minor injury or friction, such as rubbing or scratching.
What is Plex and do I need it?
Plex gives you one place to find and access all the media that matters to you. From personal media on your own server, to free and on-demand Movies & Shows, live TV, podcasts, and web shows, to streaming music, you can enjoy it all in one app, on any device.
What is Plecs Blockset?
PLECS Blockset is a unique tool for the fast simulation of power electronic circuits within the Simulink environment. It allows combined simulations of electrical circuits modeled in PLECS with controls modeled in Simulink.
Is Nebulin a contractile protein?
Nebulin is an actin-binding protein which is localized to the thin filament of the sarcomeres in skeletal muscle. It is a very large protein (600–900 kDa) and binds as many as 200 actin monomers….Nebulin.
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What is the function of vinculin?
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane.
Is EB fatal?
EB can vary from minor to fatal. The minor forms causes blistering of the skin. The fatal forms affect other organs. Most types of this condition start at birth or soon after.
What is the function of the plectin protein?
Plectin is a giant protein found in nearly all mammalian cells which acts as a link between the three main components of the cytoskeleton: actin microfilaments, microtubules and intermediate filaments.
Is it normal to have protein in your urine?
Protein is normally found in the blood. If there is a problem with your kidneys, protein can leak into your urine. While a small amount is normal, a large amount of protein in urine may indicate kidney disease. Other names: urine protein, 24-hour urine protein; urine total protein; ratio; reagent strip urinalysis.
Is plectin a biomarker for pancreatic cancer?
Plectin has been proposed as a biomarker for pancreatic cancer. Although normally a cytoplasmic protein, plectin is expressed on the cell membrane in pancreatic ductal adenocarcinoma (PDAC) and can therefore be used to target PDAC cells.
What does plec1 stand for?
Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as “hemidesmosomal protein 1” or “plectin 1, intermediate filament binding 500kDa”. These names were superseded by plectin.
