AE1/AE3 is an antibody cocktail that is used in immunohistochemistry, being generally positive in the cytoplasm of carcinomas (cancers of epithelial origin).
What is cytokeratin AE1 AE3?
As its name implies, cytokeratin AE1/AE3 is a mixture of two different clones of anti-cytokeratin monoclonal antibodies, AE1 and AE3. Both of these individual clones detect certain high and low molecular weight keratins.
What does AE1 AE3 negative mean?
The most common carcinoma that is negative for cytokeratin AE1/AE3 is hepatocellular carcinoma.
What is anti pan antibody?
Monoclonal Anti Pan Cytokeratin is a broadly reactive reagent, which recognizes epitopes present in most human epithelial tissues. It facilitates typing of normal, metaplastic and neoplastic cells. There are two types of cytokeratins the acidic type I cytokeratins and the basic or neutral type II cytokeratins.
What is the difference between keratin and cytokeratin?
As nouns the difference between keratin and cytokeratin is that keratin is (protein) a protein which hair and nails are comprised of while cytokeratin is either of several forms of keratin found in the intracytoplasmic cytoskeleton of epithelial tissue.
Where is cytokeratin found?
A type of protein found on epithelial cells, which line the inside and outside surfaces of the body. Cytokeratins help form the tissues of the hair, nails, and the outer layer of the skin. They are also found on cells in the lining of organs, glands, and other parts of the body.
What is Pancytokeratin?
Product Description. Pan Cytokeratin [AE1/AE3] antibody recognizes the acidic and basic (Type I and II) subfamilies of cytokeratins. The cocktail of these two antibodies has been shown to detect in human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48 46, 45 and 40 kDa.
What type of cytoskeleton is cytokeratin used in diagnosing carcinoma?
Cytokeratins are keratin proteins found in the intracytoplasmic cytoskeleton of epithelial tissue.
Where is cytokeratin produced?
What is AE1/AE3 antibody?
Pan Cytokeratin [AE1/AE3] antibody recognizes the acidic and basic (Type I and II) subfamilies of cytokeratins. The cocktail of these two antibodies has been shown to detect in human epithelia.
What is Pan cytokeratin antibody used for?
In immunohistochemistry studies, this Pan Cytokeratin antibody has proven useful as a screener for the majority of human carcinomas. 1. Bunton TE. The immunocytochemistry of cytokeratin in fish tissues.
What are the alternative versions of the cytokeratin antibody?
Alternative Versions Anti-pan Cytokeratin antibody [AE1/AE3] (ab226477) Anti-pan Cytokeratin antibody [AE1/AE3] – BSA and Azide free (ab80826) Compatible Secondaries Goat Anti-Mouse IgG H&L (Alexa Fluor® 488) (ab150113) Goat Anti-Mouse IgG H&L (HRP) (ab205719) Immunohistochemistry kits Mouse on Mouse Polymer IHC Kit (ab127055)
What is the molecular weight of a cytokeratin antibody?
The cocktail of these two antibodies has been shown to detect in human epithelia. The acidic cytokeratins have molecular weights of 56.5, 55, 51, 50, 50, 48 46, 45 and 40 kDa. The basic cytokeratins have molecular weights of 65-67, 64, 59, 58, 56 and 52 kDa.
